Anti-Heparanase1抗體說(shuō)明書(shū)

Catalog Number : Rs-1541R

Quantity size :   0.1ml  （dilute with pH 7.4    0.01 M PBS or antibody diluent ）

Background:

Heparanase1 is an endo-beta-D-glucuronidase, which degrades heparan sulfate side chains of heparan1 sulfate proteoglycans （HSPGs） in the extracellular matrix. Heparanase plays an important role in ECM degradation, facilitating the migration and extravasations of tumor cells and inflammatory leukocytes. Upon degradation, heparanase releases growth factors and cytokines that stimulate cell proliferation and chemotaxis. Heparanase is a heterodimer comprised of a 50 kDa subunit harboring the active site and an 8 kDa subunit. It is produced as a latent 65 kDa precursor and proteolytically processed to its active form. Heparanase is highly expressed in myeloid leukocytes （i.e. neutrophils） in plaets and in human placenta. Human heparanase was found to be upregulated in various types of primary tumors, correlating in some cases with increased tumor invasiveness and vascularity and with poor prospective survival.

pecificity :   

–         Anti-Heparanase1  is a rabbit  polyclonal antibody unconjugated                

–         specific fo  Heparanase1 of human, mouse, rat，cow     

–         use for western blotting,elisa,immunoprecipitation and immunohistochemistry

–         Protein G affinity chromatography purification, purity :>95%

–         Isotype:  IgG

–         mol wt:  12.5 kDa

Application :  

–        Western blotting 1:100-500            

–         Immunohistochemistry 1:100-500                 

–         ELISA 1:500-1000                   

–         Optimal working dilutions must  be determined by the end user.

Storage:  Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. The  lyophilized antibody is stable at room temperature for at least one month and for greater  than a year when kept at -20℃. When reconstituted in sterile pH 7.4 0.01M PBS or diluent  of antibody, the antibody is stable for at least six weeks at 2-4 ℃

Important Note: This product as supplied is intended for research use only, not for use in  human, therapeutic or diagnostic applications.

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